Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial

N Cheng; A Mclaverty; B Nelson; C Markulev; MR Schäfer; M Berger; N Mossaheb; M Schlögelhofer; S Smesny; IB Hickie; GE Berger; EYH Chen; L De Haan; DH Nieman; M Nordentoft; A Riecher-Rössler; S Verma; R Street; A Thompson; HP Yuen; R Hester; AR Yung; PD Mcgorry; K Allott; GP Amminger

Journal article

Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial

N Cheng, A Mclaverty, B Nelson, C Markulev, MR Schäfer, M Berger, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, GE Berger, EYH Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler, S Verma, R Street, A Thompson, HP Yuen Show all

Bjpsych Open | Published : 2022

DOI: 10.1192/bjo.2022.572

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Abstract

Background Cognitive impairments are well-established features of psychotic disorders and are present when individuals are at ultra-high risk for psychosis. However, few interventions target cognitive functioning in this population. Aims To investigate whether omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation improves cognitive functioning among individuals at ultra-high risk for psychosis. Method Data (N = 225) from an international, multi-site, randomised controlled trial (NEURAPRO) were analysed. Participants were given omega-3 supplementation (eicosapentaenoic acid and docosahexaenoic acid) or placebo over 6 months. Cognitive functioning was assessed with the Brief Assessment..

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University of Melbourne Researchers

Barnaby Nelson Author

Connie Markulev Author

Maximus Berger Author

Eric Yu Hai Chen Author

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Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This work was supported by grant 07TGF-1102 from the Stanley Medical Research Institute, grant 566529 from the National Health and Medical Research Council of Australia (NHMRC) Australia Program (to P.D.M., I.B.H., A.R.Y. and G.P.A.) and a grant from the Colonial Foundation. K.A. was supported by a Career Development Fellowship from the NHMRC (1141207) and a Dame Kate Campbell Fellowship from The University of Melbourne; G.P.A. and A.R.Y. were supported by NHMRC Senior Research Fellowships 1080963 and 566593 respectively; B.N. was supported by NHMRC Career Development Fellowship 1027532; and P.D.M. was supported by NHMRC Senior Principal Research Fellowship 1060996.